Three clocks, three locked milligrams
Lay the three filed milligrams on one parchment. Cialis 20 mg once is a PRN almond with a long tail, not a breakfast strip. Viagra 100 mg is a late diamond on an empty plate. Levitra 2.5 or 10 is an opener pair with a QT tick, not a 20 mg trophy.
None of those locks is a starter-for-everyone stamp. The labels still run their own ladders: tadalafil 10 mg PRN typical start and 2.5/5 daily; sildenafil 50 mg typical start; vardenafil 10 mg typical start. This site chose different rungs so the network does not reprint one postcard. Peel the lock. Then score the man.
This page does not rerun three monographs. It only asks how the three clocks differ once the milligrams are nailed down. For lane detail see daily versus the almond. For the Sandwich miss see the origin slip. For the QT footnote see the selectivity file.
Nitrate washouts are not twins
Nitrate washouts are not twins. The contraindication is identical: no nitrate, no popper, no riociguat, with any of the three. The clocks differ because clearance differs. After sildenafil or vardenafil, plan about 24 hours. After tadalafil, plan about 48 hours.
A longer gap is not a nastier drug. It is a longer presence in blood. Emergency teams need the INN and the hour, not 'I take something for sex.' Men who live with a nitrate spray do not get a comparison - they get a closed class.
Alpha-blockers are sequenced cautions on all three, not twins of the nitrate ban. CYP3A4 inhibitors raise all three and shrink starting doses. The holds look similar until you put the clocks on the parchment. Then tadalafil's extra day is the line residents forget.
How this bench actually chooses among the three
How this bench actually chooses among the three starts with holds, not with a crown. Nitrate life? Class closed. Dirty QT or amiodarone? Drop vardenafil. Fatty dinners that will not move? Prefer tadalafil. Need a prostate chip as well? Tadalafil 5 mg daily, not a 20 mg stack.
Want a weekend from one swallow? 10 or 20 mg tadalafil PRN - this desk's lock is 20 once after a real 10 mg trial. Want a punctual evening and an empty-enough plate? Sildenafil, and remember 100 mg is the late diamond. Want a small tablet, clean ECG, short clock? Vardenafil 10 mg, or 2.5 mg when the interaction list demands it.
Still no erection after an honest trial? Stop comparing milligrams. Open the failure workup. A PDE5 slip is one tool. Three clocks on one parchment do not replace a vascular, nerve, hormone, or mood file.
Link the three labels before you pick a clock. The tadalafil slip owns the long tail and the prostate chip. The sildenafil slip owns the empty plate and the late diamond. The vardenafil slip owns the QT tick and the 2.5-or-10 opener. That is the whole comparison once the holds are peeled.
Fat punishes two slips and ignores one
| Locked slip | Clock | Food | Extra ink |
|---|---|---|---|
| Cialis 20 mg once | Peak ~2 h; tail up to ~36 h | Quiet | Daily 2.5/5 is another lane - do not stack |
| Viagra 100 mg | Peak ~1 h; ~4 h cover | High-fat: Cmax -29%, Tmax +~60 min | Revatio is another product |
| Levitra 2.5 or 10 | Peak ~0.5-2 h; short evening | Heavy meal can blunt | QT tick; Staxyn not a twin |
Fat punishes two slips and ignores one. Sildenafil's high-fat meal story is the sharpest: about 29 percent less Cmax and about an hour of delay. Vardenafil's film coat still blunts after a heavy plate. Tadalafil's food line is quiet - almond or chip, steak or not.
If the couple's life is dinner-then-bed and they will not move the meal, the 20 mg almond (or a daily 5 mg chip already at steady state) is the honest food pick. Escalating Viagra 100 mg to overpower a steak is how you meet PDE6 and a headache.
Empty plate is a sildenafil counseling stamp on this desk, not a moral rule. A quieter stomach is enough. Nobody needs to skip eating. They need to stop running a bioavailability trial against cream sauce.
Who peaks first on an emptier stomach
Who peaks first on an emptier stomach? Sildenafil and vardenafil share a short-clock family: Tmax often inside 30 to 120 minutes, median nearer an hour when the plate is quiet. Tadalafil's peak sits nearer two hours, then refuses to leave.
So the man who wants an evening that starts soon, and who can keep the richest course away from the tablet, may find the diamond or the 10 mg Levitra film coat more punctual. The man who wants Friday's swallow to still matter on Sunday morning wants the almond, and he can wait the extra bit to peak.
Onset is not potency. A faster peak is not a harder erection. It is a clock. I get more false failures from people who swallowed at the wrong hour than from people who picked the 'weaker' INN.
Stimulation still has to be in the room for all three. A punctual peak on an empty sofa is a quiet tablet, not a broken molecule. I would rather move the hour than swap INNs because someone sat through the Tmax window scrolling a phone.
Weekend versus an evening
Weekend versus an evening is the span question. Tadalafil's 17.5-hour half-life is why one 20 mg almond can still support a response the next day. Sildenafil and vardenafil live nearer four to five hours. Their honest promise is an evening, not a Sunday morning.
Daily tadalafil 2.5 or 5 mg is a fourth clock that only one molecule owns. It is not in the 20 mg lock. It is in the lane review. Do not put a breakfast chip in this comparison as if it were a fourth INN.
Men who have sex twice a month usually waste a daily chip. Men who refuse any countdown often waste a short-clock tablet. Match the span to the life. Do not match it to a crown.
Back ache after tadalafil is a class-adjacent nuisance some men notice more on the long molecule. Flush and headache show up on all three. I do not switch INNs for a mild flush that faded. I do switch when a nuisance is the reason the man will not take the next honest trial.
Price talk here is teaching, not a shop
Price talk here is teaching, not a shop. This desk does not invent a dollar or point at a hatch. The lesson is calendar maths. A daily 2.5 or 5 mg chip costs a tablet on days nobody has sex. A 20 mg almond costs when you open the bottle. A 100 mg diamond and a 10 mg Levitra do the same: pay per event.
Rare sex plus a daily chip is how people overpay in habit even when the pharmacy number looks 'small.' Frequent unplanned sex plus a short-clock tablet is how people overpay in mood - the countdown becomes the price. I would rather a couple name that trade than hunt a fictional bargain.
Generics exist for all three INNs in many markets. Brand names on this page are teaching labels. They are not a shopping list. If someone quotes you a number, ask which milligram, which count, and which date. This parchment will not invent one.
Only one slip carries a QT tick
Only one slip carries a QT tick. Vardenafil's label warns about QT prolongation and tells you to avoid congenital long-QT and Class IA or III antiarrhythmics. Sildenafil and tadalafil do not wear that same footnote. That single line can decide the whole comparison.
Selectivity over PDE6 runs the other way as a comfort story: tadalafil almost none, vardenafil middling, sildenafil the leakiest. Blue edges are annoying. A torsades risk is a different severity. Do not let a retina story outrank an ECG story.
If the rhythm file is dirty, I drop Levitra first, even at 2.5 mg. Selectivity will not rescue that chart. See the selectivity deep-dive for the footnote in full.
None of the three is crowned on this parchment
None of the three is crowned on this parchment. File Cialis 20 mg once as a long PRN almond, Viagra 100 mg as a late empty-plate diamond, and Levitra 2.5 or 10 as a cautious short clock with a QT tick.
Food punishes two and ignores one. Nitrate gaps run 24 versus 48 hours. Only vardenafil carries the QT footnote. Cost is a calendar, not a shop. Staxyn and Revatio stay in other drawers.
Read the three labels, then the three single-molecule dives, then decide whether a tablet belongs at all. A comparison that ends with a crown is marketing. This one ends with a flat file.
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